Job Description

Job Description

Job Description

The Program

Maze Therapeutics offers a dynamic 9-week summer internship program designed to provide hands-on experience and professional growth opportunities. As a Maze intern, you will take ownership of your own projects and gain practical insights and learning from Maze employees. You will participate in several events and trainings with your fellow interns, including professional development workshops, discussions with Maze executive leaders, and opportunities to present your research. The program concludes with a company-wide presentation and celebration. This immersive experience provides a meaningful opportunity to contribute to innovative research, grow professionally, and learn more about the biotechnology industry.

As an intern in the Protein Sciences group, you will be responsible for conducting experiments to express, purify, and biophysically characterize target proteins aligned with our current drug discovery objectives. You'll have the opportunity to collaborate with cross-functional teams within a cutting-edge biotech company and receive mentorship from scientists from across Maze—gaining exposure to diverse career paths in the biotechnology industry. The role is ideal for a student with a background in biochemistry research looking to apply academic knowledge in a real-world setting and make a meaningful impact.

• Experimental Support:
• Conduct protein expression and purification experiments to support drug discovery programs
• Perform biophysical assays such as nanoDSF, MST, or TR-FRET to characterize target protein stability and activity
• Ensure proper documentation of experiments.
• Data Collection and Analysis:
  • Record experimental data accurately and assist with data analysis using tools such as Excel, GraphPad. or other bioinformatics software.
  • Summarize findings for team presentations.
• Protocol Optimization:
  • Support the troubleshooting and optimization of experimental protocols under the supervision of experienced scientists.
• Literature Review:
  • Conduct literature reviews to support ongoing research projects and explore new techniques relevant to the project goals.
• Cross-functional Collaboration:
  • Work with teams across Maze to advance project objectives and gain exposure to different aspects of biotechnology research.
• Learning and Development:
  • Gain hands-on experience in research techniques for protein purification while fostering your professional growth.
• Organizational Support:
  • Adhere to compliance standards for safety and research integrity.

• Currently pursuing a bachelor's degree in life sciences field (Biochemistry, Biophysics, Molecular Biology), or a related discipline
• A background in biochemistry research with a willingness to learn to learn new research techniques.
• Familiarity with molecular biology techniques such as cell culture and PCR is preferred.
• Ability to assist with experimental design, record data accurately, and maintain detailed lab notebooks following Good Laboratory Practices.
• Clear communication skills, with the willingness to present findings in team meetings
• Willingness to collaborate using interpersonal skills
• Attention to detail using analytical skills and a problem-solving mindset.
• Effective time management skills to meet deadlines in a fast-paced environment.

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. We are advancing a pipeline using our Compass platform, which allows us to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process we refer to as variant functionalization. Our Compass platform has been purpose-built to inform all phases of our drug discovery and development process through clinical trial design. We are currently advancing two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease, or CKD. Our goal is to bring novel precision medicines to patients with common diseases, which is where we believe we can maximize our impact on human health.

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we'll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The internship is scheduled to commence on June 16, 2025, and will conclude on August 15, 2025 (with potential flexibility in dates).

The expected hourly rate for this role is as follows:

Undergraduate: $28.00/hour

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